In October of 2003, General Stanley McChrystal took command of the U.S. Joint Special Operations Command (JSOC). He took command when JSOC was battling Al-Qaeda in Iraq — and losing. Even with elite military forces under his new command, Al-Qaeda just kept getting stronger. JSOC forces would strike High Value Targets — leaders in Al-Qaeda — regularly and successfully, only to have the terrorist organization continue to expand and strengthen. Something was different about Al-Qaeda, and General McChrystal had to figure it out if there was any hope of success.
He was expecting to see a normal command-and-control structure in Al-Qaeda. That is how most military forces are organized. What he found was quite a shock: Al-Qaeda was nimble, elusive, and fast — faster than a top-down command structure would allow. Its structure appeared disorganized and very organizationally loose, but somehow very effective. In reality, it had many leaders who could instantly issue orders through a very modern communications system without going through a hierarchy of levels.
General McChrystal could only compete by doing the same. He reorganized the JSOC tactical structure and empowered leaders on the ground in Iraq to act without first waiting for approval from high command. Only then did the U.S. have the upper hand against Al-Qaeda, and in 2005 Al-Qaeda was finally on the run.
It’s no great stretch to compare cancer tumors to a terrorist organization. Terrorism spreads. When cancer spreads, it’s called metastasis. Cancer has a number of “leaders”, any of which can spread without needing authorization to do so. In Afghanistan, we have been reminded of how a military force that has learned to flourish in a harsh environment, and is a product of that environment, has a great advantage over a foreign military. It is not much of a stretch to compare the rapid take-over of the country by the Taliban terrorists to the spread of cancer cells in the body: given favorable conditions, both spread quite rapidly, from a few leaders to an entire take-over. In the case of cancer, we need to learn how it acts and beat it at its own game.
The Royal “We”
Have you heard yet about the comparison of a cancer tumor to a bee hive, with the cancer stem cell (CSC) being the queen bee? There are many worker bees, but they work for the queen. She can make more worker bees; in fact, that is her main job. Where there is a queen, there is either a hive or one that is forming. The scientific theory of CSC “queen bees” provides the best predictive model of cancer development, growth, and metastasis.
The cancer stem cell is the “queen”, but the tumor can have 1% to 3% of its cells being CSC’s. The “queen” is plural in the cancer tumor — there are a number of CSC’s. Like bee queens, the CSC’s produce more cancer “workers” — differentiated cells that do specific functions in the tumor.
CSC’s do not need to get any authority to take over. They are resistant to environmental stress and toxins, and capable of making either more CSC’s or differentiated cancer cells. This makes them a tough foe to beat when they leave the tumor and metastasize elsewhere in the body. Unlike normal stem cells, they are extremely resilient almost immortal (like normal stem cells), and capable of producing specialized (differentiated) cells.
Some aspects of nature are directly observable. We can see a seed germinate and science can tell you how that process works because repeated experiments yield the same observable results. But much of science is Sherlock Holmes type deduction: scientists deduce a model based on repeatable results of indirectly observable phenomenon. We can’t always see molecules very well, but we can interact with them and basically figure them out by indirect means. “Fact” in many scientific circles could be better described as “hardened theory”: the theory repeatedly matches experimental results, so we think we understand the mechanism that we can’t actually see.
Cells do not have a simple observable marking system to tell researchers “I’m a cancer stem cell” or “I’m a worker cell”. Generally cell types are determined by their actions. The CSC model best explains what is happening in a tumor: the CSC’s rapidly reproduce differentiated cells like the queen bee produces workers. The tumor spreads outward, with the CSC’s in their original position in the center of the tumor. As the tumor grows, the environment at the center of the tumor becomes more acidic, more pressurized, and less supplied with oxygen, so that only the hardy CSC’s can survive there. Cancer is born out of cellular adaptation to harsh conditions, and the toxic environment of the tumor reinforces the CSC’s. Remember, cells increase their epigenetic responses rapidly when conditions are challenging: they can actively shift DNA code segments 1000 times faster when looking for a combination that best handles a toxic environment. Since the segments already exist in the DNA, this trial and error shifting of segments to deal with threats can occur rapidly when needed.
Since a CSC is so hardy, when it does escape the tumor and travel elsewhere in the body, it has the best chance of succeeding there and building a new tumor. A research team led by scientists at the Litchfield Lab at UCL in London studied the process of metastasis by physically studying 756 tumor biopsies from different tumor regions. The study results published in Nature Ecology & Evolution showed, “…surprisingly, cells within the centre of a tumor are the most aggressive and have the highest chance of spreading around the body.” Why is that surprising, when you realize that they were probably observing the action of “queen bees”? We know CSC’s are aggressive, hardy, and are most capable of surviving the journey. Something else that should be obvious apparently surprised the authors: they found that cells at the center of tumors “have a less stable genome” than cells near the tumor edge. CSC’s are actively rearranging code segments to try to survive and even thrive in their environment. Their results provide the “queen bee” cancer theory with even more evidence.
Scientists are increasingly realizing that most cell behavior changes are due to epigenetics: segments that were there all along changed from inactive to active, thereby changing the cell behavior. Activated segments can be deactivated or “silenced” as easily as they can be activated. More and more cancer research is showing epigenetic changes are responsible for malignancy. That is a major shift in understanding cancer development.
Part of military strategy is “knowing your enemy”. Studying cancer has shifted the cancer stem cell model to a solid theory. In some circles it has reached the status of “fact”. Realizing that cancer is not just an unorganized blob of renegade cells, but an interconnected organization led by CSC’s helps us anticipate cancer’s next move. Chopping away at the differentiated “workers” of the outer portions of a tumor has some value, but doesn’t get to the core of the problem. We have to deal with the “terrorist leaders” of the tumor.
There are three possible ways to deal with cancer cells: eradicate them, control them with the immune system, or change their behavior. Is the third possibility really an option? Consider how cancer forms in the first place: normal cells altering their behavior, driven by their environment to epigenetically change their coding to deal with a threat. Why wouldn’t this be reversible? In fact, studies have used indirect cell reprogramming techniques to prod cancer cells to become induced pluripotent stem cells (iPSCs), which then can differentiate into normal cells, and also “transcription factors” to directly reprogram can29cer cells to normal cell function, as described in an article published in Cancer Communications. In one of their cited studies, published in Cell, researchers at the New York Stem Cell Foundation gave laboratory study results where iPSCs where created from cancer cells by the introduction of four factors (Oct3/4, Sox2, c Myc, and Klf4) into cell cultures.
These studies are very new, and the researchers admit that they are far from developing safe and reliable cancer therapies based upon cancer reprogramming. So we go back to what have always known: bad environmental factors promote cancer development, and good environmental factors inhibit it, even reverse it. A healthy environment gives your body a fighting chance to kill the cancer cells, isolate them via the immune system, and best of all, encourage them to behave like normal cells. Learn from the enemy and beat it at its own game. Health is the best defense, and offense, against cancer!
Dr. Nemec’s Comments:
Remember cells increase their DNA activity 1000 times faster when in a toxic inflammatory environment. This means more chance of errors and mutations.
When the queen bee cancer stem cell is in the middle of an aggressive tumor it is very hard for normal immune cells to go into that low oxygen and highly acidic environment to attack. Also if they can reprogram cancer stem cells back into normal cells in a laboratory this proves it can be done. The problem is that they are not taking into account the power of the mind, nor diet and lifestyle. You can reprogram cells short term with some medications but they will have side effects and cause other systems to go out of balance, so the only real answer is the one that has been always available to you: change your thoughts (subconscious and conscious), change your diet, and change your lifestyle. This produces an environment that has the possibility to make cancer stem cells reprogram back into normal cells with no side effects.
The reason queen bee cancer stem cells are so hard to kill is because to use a chemotherapy strong enough to target them, you would kill all the healthy stem cells which are responsible for healthy cells to continue to live, thrive and adapt. If you kill the cancer stem cells you will most likely kill your stem cells, which means healthy cells are no longer being maintained. The way normal stem cells work is like this: If you have a muscle stem cell and it divides, it makes another muscle stem cell along with a normal differentiated muscle cell. This division insures that the healthy stem cell line is maintained and the non-stem muscle cell is produced to maintain health. If you killed the muscle stem cell with strong chemotherapy then your muscles would no longer replicate and you would lose all muscles — not just legs and arms but the diaphragm and heart are muscles that keep you alive with breathing oxygen and circulating blood. So you see you cannot just go in and drop bombs everywhere — this would make your situation and health much worse. So how do you stop the queen bee cancer stem cell? First and foremost you must stop all factors that are inflaming the cells, tissues, glands and organs.
The 10 major inflamers can be seen in this video. What are the two biggest? The mind and the food. The mind produces a field of energy that controls all cellular functions. Remember your cells are listening to the environment and the greatest environmental inflamer is the subconscious and conscious stress programs that have been written on the hard drive of your brain. This constantly secretes stress hormones and neurotransmitters that shut off the immune system and prepare for growth. Why is this so very important? Because this stress never shuts off and is not even recognized because it is primarily subconscious. This is why our signature protocol of 3D Brain Imaging and Brain Mapping along with our customized Heart Brain Entrainment Therapy opens a door to release these long-held stress programs. You do not get rid of this enemy unless you change the environment permanently in body, mind and emotions.
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