Have You Considered The Cancer Stem Cell In Cancer Treatment Protocols?

• What is the cancer stem cell?
• What causes the cancer stem cell to form?
• Does chemotherapy and radiation kill the cancer stem cell?
• Is chemotherapy and radiation always necessary?
• How did you get cancer in the first place?
• Is your protocol addressing all the factors that are necessary to heal including: Diet, anti-inflammatory protocols, oxygen level, hydration level, optimal sleep patterns, cellular exercise, conscious and subconscious stressors from past, present and future?
• Is your approach measurable?
• Can you completely overcome cancer instead of trying to kill it again and again?

Cancer Stem Cells Are What Drive Cancer Growth And Spread

To heal cancer, you must cause the cancer stem cells to differentiate back into normal cells. This can only be accomplished if the proper internal environment is produced. This environment must address both physical and mental/emotional factors. When chemicals and toxins are introduced into the body, this makes cancer stem cells develop. Only when an environment that produces health is achieved will the cancer stem cells revert back to normal healthy cells.

The Answer To Cancer Is Found In The Cancer Stem Cell

A cancer stem cell is the foundational cell that produces all the other cancer cells that give a malignant tumor its size. The majority of these cancer cells are called non-stem cancer cells. Cancer can be analogous to a bee hive. In the hive the queen is responsible for the growth of the hive. If you killed all the bees but left the queen, she would lay more eggs so that more bees would be produced. The queen represents the cancer stem cell and the rest of the bees in the hive would be the non-stem cancer cells. You will never get rid of the hive until you get rid of the queen. So, it is with cancer. Unless you cause the cancer stem cell to differentiate back into a normal cell, no matter how much chemotherapy or radiation you do, no matter how much tumor shrinkage or cancer reduction you achieve, the cancer will return and be even more aggressive, growing faster. Why? Because all chemotherapies and radiation therapies do not kill the cancer stem cell.

What Causes A Normal Cell To Dedifferentiate Into A Cancer Stem Cell?

A negative change in the internal environment around the cell will cause the change. When the chemical or toxin load or the inflammation builds up to a peak level, this triggers a survival mechanism in the cells. The inflammatory disease model demonstrates that cancer forms when inflammation and toxicity build up to the point that it spills over from the blood to the space between the blood and the cells called the extracellular matrix and then finally spills over into the cell itself and enters the nucleus of the cell where the DNA and genetic material are made. When inflammation and toxins enter into the nucleus, the cell has one final attempt to survive: it dedifferentiates into a stem cell to try to adapt to a toxic environment.
Is chemotherapy the best choice when you are diagnosed with cancer? To answer this, you must look at what chemotherapy’s success rate has been. In an Australian study, researchers stated: “in lung cancer, the median survival has increased by only 2 months during the past 20 years and an overall survival benefit of less than 5 percent has been achieved in the treatment of breast, colon and head and neck cancers.” This study showed that chemotherapy’s 5-year survival in adults was 2.1 percent in the USA.

Chemotherapy does not kill cancer stem cells; it only kills the outer layers of the tumor made up of non-stem cell cancer cells. Your normal cells have an innate wisdom to transform into cancer stem cells to adapt to an inflammatory and toxic environment. When you do chemotherapy, it will cause more cancer cells to be produced in order to survive an even more toxic environment. The only logical answer to heal cancer would be to decrease the toxic load and to naturally support the function of all systems, glands and organs.

Then Is Chemotherapy Necessary?

That answer lies within you. Some people have tumors pressing on vital tissues that could take their life quickly. In those cases, the chemotherapy would be necessary. Always remember and never forget this statement: You did not get cancer from a deficiency of chemotherapy. You were diagnosed with cancer because you made an inflammatory and toxic environment in your body through your diet, lifestyle, past and present stresses. If you do chemotherapy without comprehensively addressing these areas your body will be worse off then when you started. Yes, the tumor might go away but how long to you think it will take until it comes back because YOU DID NOT kill the cancer stem cell and YOU DID toxify your cells, tissues, organs and glands to a higher degree then what triggered the cancer in the first place?

Cancer cells should not be seen as a foreign invader that needs to be destroyed. They are your cells that have adapted to survive. To get them to change back into normal cells calls for a change in the internal environment. Cancer cells grow rapidly in high inflammation, high toxins, low oxygen, high sugar and an acidic environment along with certain mental/emotional blockages that were not only consciously formed but also subconsciously programmed because of misperceptions of the situations. Cancer cells would have no reason to reproduce rapidly and spread if this environment was reversed. If you change the physical, mental and emotional environments, you increase the possibility for the cancer stem cells to revert back into normal cells. This is the first step in healing cancer. Any alternative cancer treatment must understand this basic premise in order to be successful.

If you are truly desiring to heal the cause of your cancer permanently and not just kill your non-stem cancer cells temporarily then you must have a comprehensive body/mind approach that is measurable. If you choose chemotherapy then make sure you are comprehensively and diligently working to restore your HEALTH and making an environment that does not promote cancer stem cell proliferation. At Total Health Institute we have been helping people do this for over 35 years. Our approach is measurable and that is important.

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If you or someone you know has been diagnosed with cancer make sure they watch this video to help get informed on what cancer really is, how it forms and how to heal the root cause instead of just trying to get rid of the effects (the tumor) and find out later that tumors can keep coming back if you do not treat the cause- which is the CANCER STEM CELL!

If after watching the first 7 minutes of this video you have questions on how to heal the root of your cancer call Total Health Institute at 630-871-0000 for a complementary phone consultation with Dr. Nemec or one of our health associates to have your questions answered.

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Developing treatments that effectively target the cancer stem cell population is essential for improving outcomes.

Max S. Wicha, M.D., Distinguished Professor of Oncology and director of the U-M Comprehensive Cancer Center

What are stem cells?

Every organ and type of tissue in the body contains a small number of what scientists call “adult” or “tissue” stem cells. Since most cells in the body live for just a short time, the body needs to keep making new cells to replace them. Adult stem cells ensure a continuous supply of new cells to replace old cells that wear out or are destroyed.

Stem cells have properties that make them different from ordinary cells.

  • They divide – Stem cells can divide to make exact copies of themselves – a property scientists call self-renewal.
  • They differentiate – Stem cells can differentiate to make specialized cells called progenitor cells that go on to form the organs and tissues in the human body.
  • They duplicate – Every time a stem cell divides, it makes one exact copy and one progenitor cell. When the progenitor cell divides, it produces two cells that are somewhat more specialized. Each generation of new cells is more specialized than the previous generation until, eventually, mature cells are produced.
  • They divide indefinitely – Many cells can divide to make copies of themselves, but they can only divide a certain number of times before they die. Stem cells can keep dividing indefinitely. Because stem cells are essentially immortal, the body keeps them under tight control, so they will divide only when a new supply of cells is needed.

” I have never heard of cancer stem cells being the cause of cancer and that they should be the target in treatment. Is this in the research?”

It is in the research published by the British Journal of Cancer and the International Journal of Cancer:

An increase in cancer stem cell population after primary systemic therapy is a poor prognostic factor in breast cancer

Abstract

Background:
The cancer stem cell (CSC) hypothesis has important clinical implications for cancer therapeutics because of the proposed role of CSCs in chemoresistance. The aim of this study was to investigate changes in the CSC populations before and after primary systemic therapy (PST) and their prognostic role in human breast cancer.

Results
A higher proportion of CD44+/CD24? tumour cells and ALDH1 positivity in pre-chemotherapy tissue was correlated with higher histologic grade, oestrogen receptor (ER) negativity, high Ki-67 proliferation index and basal-like subtype of breast cancer. Aldehyde dehydrogenase 1 positivity in pre-chemotherapy biopsy was also associated with a higher rate of pathologic complete response following PST. In comparisons of putative CSC populations before and after PST, the proportions of CD44+/CD24? and ALDH1+ tumour cells were significantly increased after PST. The cases with increased CD44+/CD24? tumour cell populations after PST showed high Ki-67 proliferation index in post-chemotherapy specimens and those with increased ALDH1+ tumour cell population after PST were associated with ER negativity and p53 overexpression. Furthermore, cases showing such an increase had significantly shorter disease-free survival time than those with no change or a reduced number of CSCs…

Conclusion:
The present study provides the clinical evidence that the putative CSCs in breast cancer are chemoresistant and are associated with tumour progression, emphasising the need for targeting of CSCs in the breast cancer therapeutics.

The CSC hypothesis has important clinical implications for cancer therapeutics because of the suggested role of CSCs in chemoresistance (Kakarala and Wicha, 2008). There is increasing evidence that CSCs are naturally resistant to chemotherapy on account of their quiescence, more efficient DNA repair, resistance to apoptosis and expression of drug-resistance proteins, such as ATP-binding cassette transporters (ABCG2 and ABCG5) and multidrug-resistance protein 1 transporters (Dean et al, 2005). If this is correct, a small population of chemoresistant CSCs may resist killing by conventional chemotherapy, whereas majority of tumour cells, which are differentiated cells that lack ‘stemness’, may be killed. The tumour could, therefore, regrow after chemotherapy because of the capacity for self-renewal of these CSCs.

British Journal of Cancer (2011) Published 10 May 2011

TUMOR REVERSION: CORRECTION OF MALIGNANT BEHAVIOR BY MICROENVIRONMENTAL CUES

Cancer is characterized by unrestrained proliferation and loss of organization, a process that is intimately linked to, and controlled by, reciprocal signaling between the genetically altered tumor epithelium, the stroma, the components of the basement membrane and inflammatory mediators. Much work has been done to characterize the genetics of cancer cells. In this review, we describe the experiments that have been performed, which point to the significant role of the tissue microenvironment in the developmental regulation of normal and neoplastic cells. Using a variety of model systems, the works of a number of laboratories have converged on a hypothesis where the correction of 1 or 2 signaling defects can revert tumor cells to a normal phenotype, both in vivo and in culture, even when the tumor cells possess multiple genetic and epigenetic lesions. This paradigm has been successfully used to treat acute promyelocytic leukemia, and it remains the task of biomedical researchers to identify additional targets for the reversion of other human malignancies.

Over several decades, our understanding of the pathogenesis of neoplasia has been advanced tremendously. Many oncogenes and tumor suppressor genes have been identified and characterized, and it is usually accepted that cancer is a genetic disease. Nevertheless, it is beginning to be appreciated that the interrelationships between the tumor epithelium and the tissue microenvironment play a critical role in tumorigenesis. It has been demonstrated the ability of the tissue microenvironment to control malignancy and the mechanisms of tumor initiation, progression and regression.

Collectively, these early experiments demonstrated that factors specific to the environment of the cell were required to attenuate, or to facilitate, the transforming activity of this potent oncogene. Recent work in transgenic models and specialized cell culture systems has begun to define the specific microenvironmental determinants that have the power to normalize overtly malignant cells.

A critical question is often asked: Why pursue the phenotypic reversion of malignancy? Surely it is better to look for more efficient methods of killing tumor cells? Tumors are remarkable creatures, possessed of manifold means to defeat the arsenal of therapeutics arrayed against them. Among other things, the genomic instability of tumors gives them a persistent evolutionary advantage, ensuring the survival of stronger, fitter, more aggressive cells that will go on to populate the body of their host. The approaches that have been taken show that it is possible to revert the malignant phenotype by the correction of environmental cues and by the normalization of signal transduction pathways even as the genome remains malignant and unstable. In this sense, the microenvironment can be dominant over the malignant genotype. It is of course preferable to eradicate the tumor altogether, but aggressive chemotherapy to eradicate a tumor often kills the host. The malleable nature of tumors would indicate that multiple approaches may be necessary. This raises the possibility of the long-term management of some cancers as a chronic condition in which the malignant potential of the tumor cells is constrained, perhaps for the lifetime of the patient.

Int J Cancer. Dec 10, 2003; 107(5): 688–695.

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