|Scientists at The Scripps Research Institute have discovered the details of a brain-to-body signaling circuit that enables weight loss independently of food intake. The weight-loss circuit is activated by combined signals from the neurotransmitters serotonin and adrenaline.
“Boosting serotonin signaling has been seen as a viable strategy for weight loss in people, but our results hint that boosting serotonin plus adrenaline should produce more potent effects — and there is already some evidence that that’s the case,” said the lead researcher for the study.
Serotonin signaling, which can be increased artificially by some diet and antidepressant drugs, has long been known to reduce weight. Until recently, scientists assumed that it does so largely by suppressing appetite and food intake. The principal researcher showed that serotonin changes food intake and fat levels via separate signaling pathways. “We could make the animals we studied lose fat even as they ate more,” she said. Her experiments found that serotonin’s food-intake-suppressing and weight-loss effects are separable.
Their most surprising discovery was that serotonin isn’t the sole driver of this weight-loss pathway, but works in concert with another neurotransmitter, a version of adrenaline. “That was a very interesting finding, especially since other studies suggest that these two neurotransmitters tend to oppose each other’s functions,” said researcher.
The human experience with weight-loss drugs already demonstrates such a fat-loss circuit. Serotonin-plus-adrenaline boosting therapies, the most prominent of which was fenfluramine-phentermine (“fen-phen”), have tended to do better at cutting weight than serotonin-boosting therapies alone. Unfortunately, the serotonin-boosting elements of these compounds have often been blamed for cardiovascular side effects — fenfluramine, for example, was banned by the FDA in 1997 — but in principle, future combination therapies could be designed to avoid producing such side effects.
- Cell Metabolism, Science Daily
Dr. Keith & Laurie Nemec comments on “How to Eat More and Weigh Less”
The answer to weight loss is not a magic pill, potion or drug. Stop looking for the quick fix, the temporary patch job and get to the root of the problems so you can resolve it once and for all. Weight loss comes naturally as a byproduct of getting and STAYING healthy. There are no safe shortcuts in this journey as was found when the diet pill fen-phen was taken off the market because of cardiovascular risks and side effects. So how do you become healthy? It begins with 7 Basic Steps to Total Health which are:
So, how do you eat more and weigh less? Start planting the 7 Basic Steps to Total Health every day and you will see them start to grow and eventually reap the harvest of Total Health of Body, Mind and Spirit.